ID   GLHA_CANFA     STANDARD;      PRT;   120 AA.
AC   Q9XSW8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   02-MAY-2006, entry version 37.
DE   Glycoprotein hormones alpha chain precursor (Anterior pituitary
DE   glycoprotein hormones common alpha subunit) (Follitropin alpha chain)
DE   (Follicle-stimulating hormone alpha chain) (FSH-alpha) (Lutropin alpha
DE   chain) (Luteinizing hormone alpha chain) (LSH-alpha) (Thyrotropin
DE   alpha chain) (Thyroid-stimulating hormone alpha chain) (TSH-alpha).
GN   Name=CGA;
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   MEDLINE=20329953; PubMed=10869857; DOI=10.1016/S0739-7240(00)00057-6;
RA   Yang X., McGraw R.A., Ferguson D.C.;
RT   "cDNA cloning of canine common alpha gene and its co-expression with
RT   canine thyrotropin beta gene in baculovirus expression system.";
RL   Domest. Anim. Endocrinol. 18:379-393(2000).
CC   -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta
CC       chain which confers biological specificity to thyrotropin,
CC       lutropin, follitropin and gonadotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted protein.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones alpha chain
CC       family.
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DR   EMBL; AF160250; AAD42900.1; -; mRNA.
DR   UniGene; Cfa.195; -.
DR   HSSP; P01215; 1QFW.
DR   SMR; Q9XSW8; 32-120.
DR   Ensembl; ENSCAFG00000003040; Canis familiaris.
DR   InterPro; IPR002400; GF_cysknot.
DR   InterPro; IPR000476; Glyco_hormone.
DR   PANTHER; PTHR11509; Glyco_hormone; 1.
DR   Pfam; PF00236; Hormone_6; 1.
DR   PRINTS; PR00438; GFCYSKNOT.
DR   PRINTS; PR00274; GLYCOHORMONE.
DR   ProDom; PD002047; Glyco_hormone; 1.
DR   SMART; SM00067; GHA; 1.
DR   PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1.
DR   PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1.
DR   PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1.
KW   Glycoprotein; Hormone; Signal.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    120       Glycoprotein hormones alpha chain.
FT                                /FTId=PRO_0000011635.
FT   CARBOHYD     80     80       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    106    106       N-linked (GlcNAc...) (Potential).
FT   DISULFID     35     59       By similarity.
FT   DISULFID     38     88       By similarity.
FT   DISULFID     56    110       By similarity.
FT   DISULFID     60    112       By similarity.
FT   DISULFID     87    115       By similarity.
SQ   SEQUENCE   120 AA;  13411 MW;  69C95E24C1245B0B CRC64;
     MDCYRKYAAV ILAALSVFLH ILHSFPDGEF TMQGCPECKL KENKYFSKLG APIYQCMGCC
     FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG NAKVENHTEC HCSTCYYHKS
//