ID   RIP_PLETU      STANDARD;      PRT;    28 AA.
AC   P83245;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   Ribosome-inactivating protein pleuturegin (EC 3.2.2.22) (rRNA N-
DE   glycosidase) (Fragment).
OS   Pleurotus tuberregium (White-rot fungus).
OC   Eukaryota; Fungi; Basidiomycota; Hymenomycetes; Homobasidiomycetes;
OC   Agaricales; Pleurotaceae; Pleurotus.
OX   NCBI_TaxID=38805;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Sclerotium;
RX   MEDLINE=21534275; PubMed=11676502; DOI=10.1006/bbrc.2001.5816;
RA   Wang H.X., Ng T.B.;
RT   "Isolation of pleuturegin, a novel ribosome-inactivating protein from
RT   fresh sclerotia of the edible mushroom Pleurotus tuber-regium.";
RL   Biochem. Biophys. Res. Commun. 288:718-721(2001).
CC   -!- FUNCTION: Inhibits protein synthesis in animal cells. Does not
CC       possess ribonuclease activity.
CC   -!- CATALYTIC ACTIVITY: Endohydrolysis of the N-glycosidic bond at one
CC       specific adenosine on the 28S rRNA.
CC   -!- SIMILARITY: Belongs to the ribosome-inactivating protein family.
DR   GO; GO:0030598; F:rRNA N-glycosylase activity; IDA.
DR   GO; GO:0017148; P:negative regulation of protein biosynthesis; IDA.
KW   Direct protein sequencing; Hydrolase; Protein synthesis inhibitor;
KW   Toxin.
FT   NON_TER      28     28
SQ   SEQUENCE   28 AA;  2961 MW;  49FCAB47D3DBC98A CRC64;
     ARTQPGNIAP VGDFTLYPNA PRQGHIVA
//