ID   CELR_THEFU     STANDARD;      PRT;   340 AA.
AC   O87590;
DT   30-MAY-2000 (Rel. 39, Created)
DT   30-MAY-2000 (Rel. 39, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   HTH-type transcriptional regulator celR.
GN   Name=celR;
OS   Thermomonospora fusca.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptosporangineae; Nocardiopsaceae; Thermobifida.
OX   NCBI_TaxID=2021;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ER1;
RX   MEDLINE=99240693; PubMed=10224066; DOI=10.1074/jbc.274.19.13127;
RA   Spiridonov N.A., Wilson D.B.;
RT   "Characterization and cloning of celR, a transcriptional regulator of
RT   cellulase genes from Thermomonospora fusca.";
RL   J. Biol. Chem. 274:13127-13132(1999).
CC   -!- FUNCTION: Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA-
CC       3' in the upstream regions of cellulase genes; these operator
CC       sequences are modulated by cellobiose.
CC   -!- SIMILARITY: Contains 1 HTH lacI-type DNA-binding domain.
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CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
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DR   EMBL; AF086819; AAC42987.1; -.
DR   HSSP; P03023; 1LCC.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_like_DNA.
DR   InterPro; IPR001761; PeriplaBP/Lac1.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF00532; Peripla_BP_1; 1.
DR   PROSITE; PS00356; HTH_LACI_1; FALSE_NEG.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
KW   DNA-binding; Transcription regulation.
FT   DOMAIN        1     61       HTH lacI-type.
FT   DNA_BIND      9     28       H-T-H motif (By similarity).
SQ   SEQUENCE   340 AA;  36864 MW;  BBE82B8EC77E7A2E CRC64;
     MERRRRPTLE MVAALAGVGR GTVSRVINGS DQVSPATREA VKRAIKELGY VPNRAARTLV
     TRRTDTVALV VSENNQKLFA EPFYAGIVLG VGVALSERGF QFVLATGRSG IEHERLGGYL
     AGQHVDGVLL LSLHRDDPLP QMLDEAGVPY VYGGRPLGVP EEQVSYVDID NIGGGRQATQ
     RLIETGHRRI ATIAGPQDMV AGVERLQGYR EALLAAGMEY DETLVSYGDF TYDSGVAAMR
     ELLDRAPDVD AVFAASDLMG LAALRVLRAS GRRVPEDVAV VGYDDSTVAE HAEPPMTSVN
     QPTELMGREM ARLLVDRITG ETTEPVRLVL ETHLMVRESG
//