ID   PKWA_THECU     STANDARD;      PRT;   742 AA.
AC   P49695;
DT   01-FEB-1996 (Rel. 33, Created)
DT   01-FEB-1996 (Rel. 33, Last sequence update)
DT   25-OCT-2004 (Rel. 45, Last annotation update)
DE   Probable serine/threonine-protein kinase pkwA (EC 2.7.1.37).
GN   Name=pkwA; Synonyms=pkw1;
OS   Thermomonospora curvata.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptosporangineae; Thermomonosporaceae; Thermomonospora.
OX   NCBI_TaxID=2020;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCM 3352;
RX   MEDLINE=96200125; PubMed=8631732;
RA   Janda L., Tichy P., Spizek J., Petricek M.;
RT   "A deduced Thermomonospora curvata protein containing serine/threonine
RT   protein kinase and WD-repeat domains.";
RL   J. Bacteriol. 178:1487-1489(1996).
CC   -!- FUNCTION: May play a regulatory role during the complex growth
CC       cycle and in secondary metabolite production.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family.
CC   -!- SIMILARITY: Contains 7 WD repeats.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF115313; AAB05822.1; -.
DR   HSSP; P16649; 1ERJ.
DR   InterPro; IPR011009; Kinase_like.
DR   InterPro; IPR000719; Prot_kinase.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR001680; WD40.
DR   InterPro; IPR011046; WD40_like.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   ProDom; PD000018; WD40; 5.
DR   SMART; SM00320; WD40; 7.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 5.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
KW   ATP-binding; Repeat; Serine/threonine-protein kinase; Transferase;
KW   WD repeat.
FT   DOMAIN       16    266       Protein kinase.
FT   NP_BIND      22     30       ATP (By similarity).
FT   BINDING      44     44       ATP (By similarity).
FT   ACT_SITE    138    138       Proton acceptor (By similarity).
FT   DOMAIN      301    394       Pro/Glu/Asp-rich (spacer).
FT   REPEAT      455    496       WD 1.
FT   REPEAT      497    538       WD 2.
FT   REPEAT      539    580       WD 3.
FT   REPEAT      581    621       WD 4.
FT   REPEAT      622    663       WD 5.
FT   REPEAT      664    705       WD 6.
FT   REPEAT      706    742       WD 7.
SQ   SEQUENCE   742 AA;  78950 MW;  AC1734640DB4383D CRC64;
     MIEPLQPGDP GRIGPYRLVS RLGAGGMGQV FLARSPGGRP VVVKVILPEY ANDDEYRIRF
     AREVEAARRV GGFHTAQVID ADPTADPPWM ATAYIPGPSL RKAVTERGPL YGNNLRTLAA
     GLVEGLAAIH ACGLVHRDFK PSNIVLAADG PRVIDFGVAR PLDSSVMTQS GAVIGTLAYM
     SPEQTDGSQV GPASDVFSLG TVLAFAATGR SPFMADSIGE IIARISGPPP ELPELPDDLR
     ELVYACWEQN PDLRPTTAEL LAQLSTDHTG DDWPPPHLSD LIGSMLPLGA TTSPNPSLAI
     EPPPPSHGPP RPSEPLPDPG DDADEPSAEK PSRTLPEPEP PELEEKPIQV IHEPERPAPT
     PPRPREPARG AIKPKNPRPA APQPPWSPPR VQPPRWKQLI TKKPVAGILT AVATAGLVVS
     FLVWQWTLPE TPLRPDSSTA PSESADPHEL NEPRILTTDR EAVAVAFSPG GSLLAGGSGD
     KLIHVWDVAS GDELHTLEGH TDWVRAVAFS PDGALLASGS DDATVRLWDV AAAEERAVFE
     GHTHYVLDIA FSPDGSMVAS GSRDGTARLW NVATGTEHAV LKGHTDYVYA VAFSPDGSMV
     ASGSRDGTIR LWDVATGKER DVLQAPAENV VSLAFSPDGS MLVHGSDSTV HLWDVASGEA
     LHTFEGHTDW VRAVAFSPDG ALLASGSDDR TIRLWDVAAQ EEHTTLEGHT EPVHSVAFHP
     EGTTLASASE DGTIRIWPIA TE
//