ID   KPYK_TRIRE     STANDARD;      PRT;   538 AA.
AC   P31865;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   21-MAR-2006, entry version 44.
DE   Pyruvate kinase (EC 2.7.1.40) (PK).
GN   Name=pki1;
OS   Trichoderma reesei (Hypocrea jecorina).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Hypocrea.
OX   NCBI_TaxID=51453;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93366185; PubMed=8359694; DOI=10.1016/0378-1119(93)90430-B;
RA   Schindler M., Mach R.L., Vollenhofer S.K., Hodits R., Gruber F.,
RA   Visser J., de Graaff L., Kubicek C.P.;
RT   "Characterization of the pyruvate kinase-encoding gene (pki1) of
RT   Trichoderma reesei.";
RL   Gene 130:271-275(1993).
CC   -!- CATALYTIC ACTIVITY: ATP + pyruvate = ADP + phosphoenolpyruvate.
CC   -!- COFACTOR: Magnesium and potassium (By similarity).
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from
CC       D-glyceraldehyde 3-phosphate: step 5 [final step].
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the pyruvate kinase family.
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DR   EMBL; L07060; AAA02922.1; -; Unassigned_DNA.
DR   PIR; JN0780; JN0780.
DR   HSSP; P00549; 1A3W.
DR   InterPro; IPR011037; PK_B_barrel_like.
DR   InterPro; IPR001697; Pyruvate_kinase.
DR   PANTHER; PTHR11817; Pyruvate_kinase; 1.
DR   Pfam; PF00224; PK; 1.
DR   Pfam; PF02887; PK_C; 1.
DR   PRINTS; PR01050; PYRUVTKNASE.
DR   ProDom; PD001009; Pyruvate_kinase; 2.
DR   TIGRFAMs; TIGR01064; pyruv_kin; 1.
DR   PROSITE; PS00110; PYRUVATE_KINASE; 1.
KW   Glycolysis; Kinase; Magnesium; Metal-binding; Phosphorylation;
KW   Transferase.
FT   CHAIN         1    538       Pyruvate kinase.
FT                                /FTId=PRO_0000112119.
FT   ACT_SITE    263    263       By similarity.
FT   METAL       265    265       Magnesium (Potential).
FT   METAL       286    286       Magnesium (Potential).
FT   METAL       287    287       Magnesium (Potential).
FT   BINDING     360    360       ADP (Potential).
FT   MOD_RES      45     45       Phosphoserine (Potential).
SQ   SEQUENCE   538 AA;  58888 MW;  E9C26AC0E8186FE7 CRC64;
     MSQISRTQSI MATTAQEHLE TGGRINWLAS LNTAFTPARN FRRTSIICTI GPKTNSVEAL
     NKLRDAGLNV ARMNFSHGSY EYHQSVIDNV RASVAAHPGR PVAIALDTKG PEIRTGNTAG
     DVDIPISAGT VMNFTTDEKY ATACDTQNMY VDYKNITKVI QPGRVIYVDD GVLAFDVLSI
     KDDQTVEVRA RNNGFISSRK GVNLPNTDVD LPALSEKDKA DLRFGVKNNV DMVFASFIRR
     AQDIKDIRDV LGPEGKQIQI IAKIENRQGL NNFAEILEET DGVMVARGDL GIEIPAAEVF
     AAQKKMIAMC NIAGKPVICA TQMLESMIKN PRPTRAEISD VGNAVTDGAD CVMLSGETAK
     GNYPAESIHE MHEASLKAEN TIPYVSHFEE MCTLVKRPVS TVESCAMAAV RASLDLGAGG
     IIVLSTSGDS ARLLSKYRPV CPIFMVTRNP TTSRFSHLYR GVYPFLYPEQ KPDFDTVNWQ
     EDVDKRIKWA VTRAIELKTL TAGDTVVVVQ GWKGGMGNTN TLRIVRADPD HLGIGQME
//