ID   KPC1_ASPNG     STANDARD;      PRT;  1096 AA.
AC   Q00078;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   04-APR-2006, entry version 48.
DE   Protein kinase C-like (EC 2.7.11.13).
GN   Name=pkcA;
OS   Aspergillus niger.
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus.
OX   NCBI_TaxID=5061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=96158841; PubMed=8569684; DOI=10.1007/s004380050047;
RA   Morawetz R., Lendenfeld T., Mischak H., Muehlbauer M., Gruber F.,
RA   Goodnight J., de Graaff L.H., Visser J., Mushinski J.F., Kubicek C.P.;
RT   "Cloning and characterisation of genes (pkc1 and pkcA) encoding
RT   protein kinase C homologues from Trichoderma reesei and Aspergillus
RT   niger.";
RL   Mol. Gen. Genet. 250:17-28(1996).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. PKC
CC       subfamily.
CC   -!- SIMILARITY: Contains 2 phorbol-ester/DAG-type zinc fingers.
CC   -!- SIMILARITY: Contains 2 REM (Hr1) repeats.
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DR   EMBL; U10549; AAA97433.1; -; Genomic_DNA.
DR   PIR; S61917; S61917.
DR   HSSP; P31751; 1GZK.
DR   InterPro; IPR000008; C2.
DR   InterPro; IPR002219; DAG_PE_bd.
DR   InterPro; IPR011009; Kinase_like.
DR   InterPro; IPR000961; Pkinase_C.
DR   InterPro; IPR011072; PKN_effector.
DR   InterPro; IPR000719; Prot_kinase.
DR   InterPro; IPR000861; REM_rpt_rho_bd.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00130; C1_1; 2.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF02185; HR1; 2.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF00433; Pkinase_C; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00742; Hr1; 2.
DR   SMART; SM00133; S_TK_X; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 2.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 2.
KW   ATP-binding; Kinase; Metal-binding; Nucleotide-binding;
KW   Phorbol-ester binding; Repeat; Serine/threonine-protein kinase;
KW   Transferase; Zinc; Zinc-finger.
FT   CHAIN         1   1096       Protein kinase C-like.
FT                                /FTId=PRO_0000055742.
FT   REPEAT        5     77       REM 1.
FT   REPEAT      160    235       REM 2.
FT   DOMAIN      771   1030       Protein kinase.
FT   ZN_FING     459    507       Phorbol-ester/DAG-type 1.
FT   ZN_FING     527    577       Phorbol-ester/DAG-type 2.
FT   NP_BIND     777    785       ATP (By similarity).
FT   ACT_SITE    896    896       Proton acceptor (By similarity).
FT   BINDING     800    800       ATP (By similarity).
SQ   SEQUENCE   1096 AA;  122235 MW;  859B2DB3B30D5BD8 CRC64;
     MDGDDLIASV YRKIEREKAL ITAASNMRQS TDNPLVQQRV DANIRDGRKN IAYLEEKMRE
     LQLRRMEHEG GGSPTDKRLP PNPEAGPVPP QKDYGPGYGG NEEYGDASGA YPHGGAGSMP
     SGAPYADPRP FAPVPKARPN YTKLDLIKYD TQYLGPKIQL MLSQLEFKLS VEKQYKAGIE
     KMVRLYQDEG DRKSRADAEG RRIESNQKIQ LLKQALKRYE DLHVDIESTD TPDDESLSTP
     NLRKPLTGLL TLRIHAVKDV DHAASSRFSR GPETFIVLKV EDTIKARTKA TRIDRWQDET
     FNIDIDKANE IELTVYDKSG DRPTPIGMLW VRISDIAEEM RRKKIESEFN ASGWVSADKM
     EHGGAPGRPD TAGGAGSAHP SGPGGPGAAP SQGYGDGSAG APAGNQVMID SWFALEPVGR
     IYLSMSFAKQ LKDRRPFDIG LNRQGAVRQK KEEVHEKQGH KFVTQQFYNI MRCALCGDFL
     KYAAGMQCAD CKYTCHKKCY PKVVTKCISK ANYETDPDEE KINHRIPHRF EGFSNISANW
     CCHCGYLLPF GRKNAKRCTE CGLTCHSHCT HLVPDFCGMS MEAANQILET LIRTKNHNKT
     ASVSSGLSGR TLRPSGTPQG PQDSAAMAYP QKPVESPYGA PQRQPSAEAV SAATNSYMPP
     QSPTAAARQQ MPPRTSSSAA VAAATVATGM PSPQQMPAEQ NRPMQPQLPT YDPKAYEPYA
     NAPQGMPPQA IQHAAPAGYG MPAQQPAMQM VSQQPPEAPQ QPKVRIGLDH FNFLAVLGKG
     NFGKVMLAET KSTKRLYAIK VLKKEFIIEN DEVESTKSEK RVFMIANKER HPFLLNLHAC
     FQTETRVYFV MEYISGGDLM LHIQRGQFGL KRAQFYAAEV LLALKYFHEN GVIYRDLKLD
     NIMLTLDGHI KVADYGLCKE NMWYGATTST FCGTPEFMAP EILLDKRYGR AVDWWAFGVL
     IYQMLLQQSP FRGEDEDEIY DAILADEPLY PIHMPRDSVS ILQKLLTREP ELRLGSGPTD
     AQEVMSHAFF RNINWDDIYH KRVPPPFLPQ ISSPTDTSNF DQEFTSVTPV LTPVQSVLSQ
     AMQEEFRGFS YTADFA
//