ID   DCXR_TRIRE     STANDARD;      PRT;   266 AA.
AC   Q8NK50;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   07-MAR-2006, entry version 17.
DE   L-xylulose reductase (EC 1.1.1.10) (XR).
GN   Name=lxr1;
OS   Trichoderma reesei (Hypocrea jecorina).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Hypocrea.
OX   NCBI_TaxID=51453;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ENZYME ACTIVITY.
RX   MEDLINE=22005794; PubMed=12009906; DOI=10.1021/bi025529i;
RA   Richard P., Putkonen M., Vaeaenaenen R., Londesborough J.,
RA   Penttilae M.;
RT   "The missing link in the fungal L-arabinose catabolic pathway,
RT   identification of the L-xylulose reductase gene.";
RL   Biochemistry 41:6432-6437(2002).
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of L-xylulose,
CC       D-xylulose, D-fructose, and L-sorbose, with the highest affinity
CC       for L-xylulose.
CC   -!- CATALYTIC ACTIVITY: Xylitol + NADP(+) = L-xylulose + NADPH.
CC   -!- PATHWAY: L-arabinose pathway; third step.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF375616; AAM20896.1; -; mRNA.
DR   HSSP; Q9ZFY9; 1FK8.
DR   InterPro; IPR002347; ADH_short_C2.
DR   InterPro; IPR002198; SDR.
DR   PANTHER; PTHR19410; ADH_short; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; FALSE_NEG.
KW   Carbohydrate metabolism; NADP; Oxidoreductase; Xylose metabolism.
FT   CHAIN         1    266       L-xylulose reductase.
FT                                /FTId=PRO_0000054558.
FT   NP_BIND      23     53       NADP (By similarity).
FT   ACT_SITE    174    174       Proton acceptor (By similarity).
FT   ACT_SITE    178    178       By similarity.
FT   BINDING     159    159       Substrate (By similarity).
SQ   SEQUENCE   266 AA;  28478 MW;  1CF56334DA86F109 CRC64;
     MPQPVPTANR LLDLFSLKGK VVVVTGASGP RGMGIEAARG CAEMGADLAI TYSSRKEGAE
     KNAEELTKEY GVKVKVYKVN QSDYNDVERF VNQVVSDFGK IDAFIANAGA TANSGVVDGS
     ASDWDHVIQV DLSGTAYCAK AVGAHFKKQG HGSLVITASM SGHVANYPQE QTSYNVAKAG
     CIHLARSLAN EWRDFARVNS ISPGYIDTGL SDFIDEKTQE LWRSMIPMGR NGDAKELKGA
     YVYLVSDASS YTTGADIVID GGYTTR
//