ID   KPC1_TRIRE     STANDARD;      PRT;  1139 AA.
AC   Q99014;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   04-APR-2006, entry version 48.
DE   Protein kinase C-like (EC 2.7.11.13).
GN   Name=pkc1;
OS   Trichoderma reesei (Hypocrea jecorina).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Hypocrea.
OX   NCBI_TaxID=51453;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=QM9414 / Rut C-30;
RX   MEDLINE=96158841; PubMed=8569684; DOI=10.1007/s004380050047;
RA   Morawetz R., Lendenfeld T., Mischak H., Muehlbauer M., Gruber F.,
RA   Goodnight J., de Graaff L.H., Visser J., Mushinski J.F., Kubicek C.P.;
RT   "Cloning and characterisation of genes (pkc1 and pkcA) encoding
RT   protein kinase C homologues from Trichoderma reesei and Aspergillus
RT   niger.";
RL   Mol. Gen. Genet. 250:17-28(1996).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Stimulated about twofold by phospholipids or
CC       phorbol esters.
CC   -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. PKC
CC       subfamily.
CC   -!- SIMILARITY: Contains 2 phorbol-ester/DAG-type zinc fingers.
CC   -!- SIMILARITY: Contains 2 REM (Hr1) repeats.
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DR   EMBL; U10016; AAA97432.1; -; Unassigned_DNA.
DR   PIR; S61918; S61918.
DR   HSSP; P31751; 1GZK.
DR   InterPro; IPR000008; C2.
DR   InterPro; IPR002219; DAG_PE_bd.
DR   InterPro; IPR011009; Kinase_like.
DR   InterPro; IPR000961; Pkinase_C.
DR   InterPro; IPR011072; PKN_effector.
DR   InterPro; IPR000719; Prot_kinase.
DR   InterPro; IPR000861; REM_rpt_rho_bd.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00130; C1_1; 2.
DR   Pfam; PF02185; HR1; 2.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF00433; Pkinase_C; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00742; Hr1; 2.
DR   SMART; SM00133; S_TK_X; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 2.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 2.
KW   ATP-binding; Kinase; Metal-binding; Nucleotide-binding;
KW   Phorbol-ester binding; Repeat; Serine/threonine-protein kinase;
KW   Transferase; Zinc; Zinc-finger.
FT   CHAIN         1   1139       Protein kinase C-like.
FT                                /FTId=PRO_0000055745.
FT   REPEAT        5     77       REM 1.
FT   REPEAT      154    229       REM 2.
FT   DOMAIN      814   1073       Protein kinase.
FT   ZN_FING     454    502       Phorbol-ester/DAG-type 1.
FT   ZN_FING     522    572       Phorbol-ester/DAG-type 2.
FT   NP_BIND     820    828       ATP (By similarity).
FT   COMPBIAS    667    678       Poly-Ala.
FT   COMPBIAS    733    739       Poly-Gln.
FT   COMPBIAS    762    768       Poly-Gln.
FT   ACT_SITE    939    939       Proton acceptor (By similarity).
FT   BINDING     843    843       ATP (By similarity).
SQ   SEQUENCE   1139 AA;  126055 MW;  937BB0DAB727B65C CRC64;
     MNEDEAIQNI TKKIEREKAL INAANAMRSQ TNNEAVRSPL DSQMRDGRRN LQFFEEKLRD
     IQLRKVGQGV EGMSLGADDA GRPPPPPKDA SSAAWGDQAA YGQQSQVGPP SDLAPPRHNF
     GAPGPGAASK ARPNFTKLDL IKYDTPYLGP RIQHMLSQIQ FKLNVEEQYL KGVEKMVQLY
     GMEGDRKSKA DAAARRVESK QKILLLKQAL KRYEELHVDM DSADAQDDDS INTPNLRKPL
     SGQLSIRVVA IKDVDHATTG RFARGPETFV AVKVEDTVMA RTKVSRNDRW EAEYHNMEVD
     KANEIELTIY DKPGEHPMPI AMLWVRISDI VEEMRRKRIE AEMNSSGWVS ADRMGSTGAP
     SQFPMSPTSG SFGGSPQAPG GGQGQAPGPF GDPAPQPQVV TGPIDGWFNL EPAGQIQLEF
     SFVKENRDKR QVDLGLGRKG AVRQRKEEVH EMFGHKFVQH QFYNIMPCAL CGDFLKYSAG
     MQCEDCKYTC HNKCYPSVVT KCISKSNAET DPDEEKINHR IPHRFQPFSN VTANWCCHCG
     YILPFGKKNC RKCSECGLTS HAQCVHLVPD FCGMSMAVAN QILEGIRVQK QRQQKTTSLS
     EKTLRSGATK SPTTAGHGSS ASFSSAGAGS VPGTPSAEAT EAARLMYNQT SPQRPGQPGR
     APSDLSAAAA ASAAMAAAQG RTGYDSGPQD PYGQGHYGAA GPAPQHHKYN PADYANVDQG
     FPAQPPAQQR PPQPQQQQQA PPAQMPPQQP PPQQPLPPQP GQQYQQQQPA AQKPQPQPPA
     TAQGAAAGPP GSQRKALPSA TDPGTGARIG LDHFNFLAVL GKGNFGKVML AETKRSKRLF
     AIKVLKKEFI IENDEVESIK SEKRVFLIAN RERHPFLTNL HACFQTETRV YFVMEYISGG
     DLMLHIQRGQ FGTKRAQFYA AEVCLALKYF HENGVIYRDL KLDNIMLTLD GHIKIADYGL
     CKEDMWYGST TSTFCGTPEF MAPEILLDKK YGRAVDWWAF GVLIYQMLLQ QSPFRGEDED
     EIYDAILADE PLYPIHMPRD SVSILQKLLT REPDQRLGSG PTDAQEVMSQ PFFRNINWDD
     IYHKRVQPPF LPQIKSATDT SNFDSEFTSV TPVLTPVQSV LSQAMQEEFR GFSYTADLD
//